Eran Eyal (CB, School of Medicine, University of Pittsburgh)
Thursday, 7.2.2008, 13:30
Multiple sequence alignments possess important information, not only about functionally and structurally important conserved regions, but also about coupling between residues. Recently we have developed a unique method to detect such coupling based on substitution matrices of residue pairs. I will describe the method and show how it performs at structural analysis tasks as contact prediction and discrimination of decoy sets. I will then show recent results that demonstrate how correlated mutations can be used to predict quaternary structures and to detect cooperatively between drug resistance mutations in HIV-1 protease. The relation between evolutionary coupling and protein dynamics, as calculated based on normal mode analysis, will be discussed.
Host: Yael Mandel-Gutfreund